Jiří - a colleague of mine, who I share my office with - has just turned 60. It was a great opportunity to eat some extra-chocolate cake and drink sparkling wine. We wish him all the best. (Motivated by Solvay conferences, we took a picture of us. Just in case...)
50th International Chemistry Olympiad
This year, the International Chemistry Olympiad (IChO) has celebrated its 50th anniversary. The first IChO took place in Prague, Czechoslovakia in 1968, and, although it is usually not emphasized, it pop up during the period known as Prague spring. Slovak and Czech republics were also the organizing countries of this year issue. It was my pleasure to be a part of Scientific committee, and with Tom Kubař to prepare and evaluate one of the eight theoretical exam problems. It was all about DNA, and part of our motivation stemmed from the work of Prof. Jan Svoboda, a famous Czech virologist in the picture below. It is just coincidence that his surname means "freedom".
New Publication in Vesmír: Göttingen Cemetery
Living in Göttingen for a couple of years, I had to visit the Town cemetery. The cemetery is famoust because of many prominent scientific figures including eight Nobel prize laureates and it is worth seeing. With Tom Kubař from Karlsruhe, we put together a text about the buried and their rich relationships when still alived. A sort of longer reading fits nicely to a summer double issue of the Vesmír journal. Just thinking, where to go next...
MPIbpc NEWS is a non-peer reviewed magazine, which highlights research of the MPI Biophysical Chemistry in Göttingen. Our contribution on ribosome simulations has recently been published and featured on the journal cover page.
The figure shows dynamics of a macrolide antibiotic (in red) bound in the ribosome exit tunnel. In bacteria, the molecule interacts with certain nascent peptides and causes ribosome stalling. No surprise that bacteria don't like it.
New Publication in Vesmír: How Are Proteins Born?
Birth - this is a fascinating topic in many areas of humanity. How it is with proteins, biomolecules that define the life as we know it? Protein are produced in ribosomes in a process called translation. According to an RNA blueprint, ribosomes catalyze peptide bond formation between amino acids and, what is more, they can regulate how proteins are produced.
Last year, I joined a conference in Cambridge, UK about so called co-translational events. A large variety of things may happen to the nascent protein before it is released from a translating ribosome. Many excellent talks in Cambridge motivated me to sum up the key ideas in a popular-science article. The article has just been published in a Czech magazine Vesmír (which has tradition since 1871!). The editorial board selected it for free-of-charge access, so you can enjoy it online without any paywall (in Czech only).
Running Proteasome on Hazel Hen
Hazel Hen, one of the largest supercomputers in Europe, has just "opened its processors" to our simulations. Our large-scale computational project has been awarded 40 million core-hours, which is a nice chunk of the supercomputing power. For comparison, it is equivalent to almost 70% of the power, which was provided for the whole Czech computational community by IT4I in its last call.
So in the next 12 months, we will run all-atom molecular dynamics simulations of the human proteasome. It is a large biomolecular complex responsible for protein degradation. Interestingly, a few drugs and drug candidates act through affecting proteasome function. We will try to uncover, how these drug affect proteasome choreography.
Current Opinion Cover Page
The Current Opinion in Structural Biology has featured our contribution on the journal cover page. Upon invitation, Helmut, Lars and me submitted a review to a special issue on Theory and simulation. Although the paper has been available since last year, the issue was released just last week. I have already posted a video about how the cover picture was done.
Making of Group Poster
I've prepared a poster about our research group. This is how it has evolved.
Another nascent peptide in the ribosome tunnel. This is a so called tnaC peptide through which the ribosome senses a level of free tryptophane. The figure shows several tnaC conformations as obtained in several μs-long molecular dynamics simulations in the absence of free tryptophane.
IT4I Project Approved
The Czech supercomputing center IT4I in Ostrava is the largest facility of this kind in the Czech Republic. To date, its supercomputer Salomon is ranked around 90th place worldwide. I applied to the latest call with a simulation project which deals with a ribosome-regulatory peptide VemP. VemP regulates translation of two bacterial gene variants by modulating the catalytic center of the ribosome. The project received an allocation of about 420 thousand corehours. Compared to our previous LRZ computational project, it is a tiny amount, but I hope it will anyway help us clarify the role of environment on the VemP structure and dynamics. The figure show the VemP in the ribosome exit tunnel. We will simulate the VemP in neat water.